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Old 02-11-2013, 01:01 AM
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Default Update on Lulu...Liver issues. :(

I'm sorry I'm just now posting this. We moved my 91 year old grandfather this weekend--very busy. My vet's assistant called me Friday afternoon and asked if I could come pick up some antibiotic for Lulu. I told him I could and asked if all the results were back from her bloodwork. They were. He gave me a copy of her blood work so that I would have it when the vet called me that evening to go over it and explain the antibiotics. I almost had a heart attack! Her AST (SGOT) should be between 15-66 was 368. ALT should be between 12-118 was 749. BUN/creatinine ratio (uric acid in urine) should be between 4-27 was 32. Cholesterol should be 92-324 was 360. Platelet count should be 170-400 was 427. The vet said she had hepatitis which in dogs can merely be an "inflammation of the liver." He also calmed me concerning her AST/ALT #s. He said that those numbers are actually considered mild to moderate. For example, had she eaten bad mushrooms those numbers could be 2000-3000s. He said the BUN/creatinine and cholesterol is tied to the AST/ALT. He can not tell me what has caused this, and he doesn't really even know if this is the cause of her weight loss as problems with the liver usually don't show up until there is already massive damage. We can only treat the symptoms. My personal belief is that her weight loss may not have been as fast as I originally thought; instead, I have not had her on as big a portion of food as she needed to maintain her weight I just noticed the weight loss when it reached a certain amount. The vet is a huge fan of ZP, but I personally believe it is too high a protein for Lulu and that is the cause of this. He did not agree with me, but he did say that she may be that rare dog that high amounts of protein are not well received by their system. I think at Lulu's age and our lifestyle (I know I will take flak for this) she is not active enough for that much protein. I would greatly appreciate thoughts on this. Also, the vet asked if I could feed her a liver cleansing diet for the next 2 weeks which, of course, I could. It is a diet prescribed by veterinarian Jean Dodd, who I really think highly of, then we will recheck her liver enzymes in 2 weeks after the diet and antibiotics.
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Old 02-11-2013, 01:05 AM
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Wow. So sorry to hear all this! Thank goodness you have a vet who investigates and gets to the bottom of things and doesn't just treat symptomatically.

I will be anxious to see how Dr. Dodds liver diet does for her. You might also want to do a milk thistle supplement and/or denarmin. Both can help with liver issues. The proof will be in the recheck of the blood work. Keep us posted.
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Old 02-11-2013, 01:06 AM
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Default Update on Lulu...Liver issues. :(

Toby's digestive system couldn't take the ZP. It was just to rich and high protein for him. Some dogs systems just can't take it. I would look into a less rich food. Sometimes the best foods just don't agree with our little ones. I put Toby on ZP and within a week his months of chronic diarrhea ended. Good luck with poor lulu.


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Old 02-11-2013, 01:15 AM
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Originally Posted by Brodysmom View Post
Wow. So sorry to hear all this! Thank goodness you have a vet who investigates and gets to the bottom of things and doesn't just treat symptomatically.

I will be anxious to see how Dr. Dodds liver diet does for her. You might also want to do a milk thistle supplement and/or denarmin. Both can help with liver issues. The proof will be in the recheck of the blood work. Keep us posted.
Thank you, Tracy. One of the antibiotics (I thought I understood it was an antibiotic) is Sam-E-Adenosyl which has milk thistle in it, and after she finishes it I believe he wants her on just milk thistle after she finishes the antibiotic.
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Old 02-11-2013, 01:19 AM
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Originally Posted by pupluv168 View Post
Toby's digestive system couldn't take the ZP. It was just to rich and high protein for him. Some dogs systems just can't take it. I would look into a less rich food. Sometimes the best foods just don't agree with our little ones. I put Toby on ZP and within a week his months of chronic diarrhea ended. Good luck with poor lulu.


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Thanks, Ashley. Yes, I LOVE ZP, but unfortunately I have to admit it may not be for all dogs. I tried Honest Kitchen, but she did not care for. Thankfully, she really liked Sojos which is also a dehydrated raw but much lower protein amount, so I think that is what I will go with when she gets off the liver cleansing diet. I can buy Sojos locally also at the holistic vet..
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Old 02-11-2013, 02:52 AM
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Originally Posted by lulu'smom View Post
Thank you, Tracy. One of the antibiotics (I thought I understood it was an antibiotic) is Sam-E-Adenosyl which has milk thistle in it, and after she finishes it I believe he wants her on just milk thistle after she finishes the antibiotic.
It's a supplement.

From a quick google search ...

S-Adenosyl (SAMe) for Dogs and Cats is used to improve liver metabolic activity and restore proper liver function. Unique, enteric-coated delivery system allows it to stand up formidably to stomach acid and effectively deliver the S-Adenosylmethionine 1,4 butanedisulfonate (SAMe) to the small intestine for proper absorption. Both strengths contain SAMe and other important ingredients for proper liver support such as milk thistle to help protect liver cells from toxins and reduce damage to those cells caused by some prescription drug use. Contains antioxidants to help neutralize oxygen free radicals, amino acids to stimulate glutathione synthesis and reduce oxidative damage, B-vitamins to provide nutritional support ensuring proper protein and energy metabolism, and vitamin B-6 for synthesis of cysteine in the liver detoxification pathway. Generic for Denosyl SD4.


I'm anxious to know how she does on it. Sounds like your vet is very thorough! Great. I think she's in great hands.
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Old 02-11-2013, 02:59 AM
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I'm anxious to know how she does on it. Sounds like your vet is very thorough! Great. I think she's in great hands.
Thank you! That means a lot coming from you!
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Old 02-11-2013, 03:15 AM
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Default Update on Lulu...Liver issues. :(

Quote:
Originally Posted by lulu'smom View Post
Thanks, Ashley. Yes, I LOVE ZP, but unfortunately I have to admit it may not be for all dogs. I tried Honest Kitchen, but she did not care for. Thankfully, she really liked Sojos which is also a dehydrated raw but much lower protein amount, so I think that is what I will go with when she gets off the liver cleansing diet. I can buy Sojos locally also at the holistic vet..
I'm glad you found something that will (hopefully) work. Please keep us updated! Hugs from Toby and I.


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