I googled and found this interesting bit of info
Jack is more prone to skin and digestive issues because of his piebald coloring. Some congenital problems - including deafness, vision issues, immune system issues, etc. - are associated with white coloring. During embryonic development, stem cells along the neural crest move and differentiate into, among other things, pigment and eye cells and ear cells and immune system cells. The piebald gene affects the mobility of these precursor cells.
Dogs are not our whole life, but they make our lifes whole