I have had one puppy shipped to me and one I flew out and picked up.
Neither one of them got sick. They mostly just sleep being as young as they are.
I would just suggest when you pick the puppy up from the airport to have Nutracal, water and some wipes with you. You might want to take a couple of pads and some puppy food with you if you have a long drive home. The wipes are in case the puppy goes potty in the crate and gets it on itself.
I have always taken mine to the vet the day after I get them. Take a stool sample so they can test for parasites.
Sandy, Koke and Lelaska's Mom