I'm supposed to be doing it 2 or 3 times a day, b/c the vet saw that my puppy had some conjunctivities when I took him in for the first time a month ago. He's a smart little guy, though, and it's to the point now where he starts squirming like crazy the second he sees the dropper. Most of it lands outside his eye. We can do the brute force thing and hold him down, but I'm ready to cry by the end of that, and he doesn't like any of us for a while after we do it that way. I expect you'll all tell me to toughen up and give him his medicine, but I just thought I would check to see if anyone had discovered some magic elixir for getting a puppy to be cooperative with eyedrops . . .