it is possible, but it's always better and safer to breed a smaller male to a bigger female. If I were to breed, I would only breed a female 4 pounds and over to a male of a smaller size. If the male is bigger and the female is really small, there is a good chance of complications. You could lose your female and/or its pups, and that is obviously not worth. Do some research before you breed so that you're prepared for anything that can happen. :wave: