I use doggie toothpaste with enzymes and chicken flavor. He thought it was TREAT and he loves them! My vet said the best is to use toothbrush! I got a cat size toothbrush from pet store! Their size is so tiny and it fits just NICE in our Chis mouth! :wink: Yoyo gets his teeth brushed at least 4 times in a week! They looks clean and shines so bright! :lol: