I use Vectra 3D for fleas, ticks, and mosquitoes (half a dose every 30 days). I also use Heartguard Plus for heart worms and intestinal parasites (one dose every two months).
In Florida, we have a really have a problem with fleas and ticks AND mosquitoes. So I think that anything that is made to prevent all three works best for us. And he has never had a reaction to either treatment.