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1. What Is Cushing's Disease In Dogs?
Cushing's disease, also known as hyperadrenocorticism in dogs, is a prevalent hormonal disorder. It happens when the dog's body produces an abnormally high level of cortisol, a hormone that regulates metabolism and the immune system. Cushing's disease can impact any breed, gender, or age of dog, but it is most frequently diagnosed in middle-aged and older dogs.

2. Causes Of Cushing's Disease In Dogs.
In pituitary-dependent Cushing's Disease, the dog's pituitary gland, located in the brain, produces too much adrenocorticotropic hormone (ACTH). ACTH stimulates the adrenal glands, which are located near the kidneys, to produce cortisol. The excess cortisol production is due to a hormonal imbalance, which can be caused by a tumor or overgrowth in the pituitary gland. Pituitary-dependent Cushing's Disease is the most common form of the condition, accounting for around 80% of all cases.
In adrenal-dependent Cushing's Disease, a tumor on one of the dog's adrenal glands causes it to produce too much cortisol directly. Adrenal-dependent Cushing's Disease is less common, accounting for around 20% of all cases. However, it can be more difficult to treat because the tumor may need to be surgically removed.
In rare cases, Cushing's Disease can also be caused by excessive administration of corticosteroid medication. This can occur if a dog is prescribed high doses of corticosteroids to treat conditions such as allergies or arthritis, for an extended period of time. In such cases, the dog's body may become dependent on the medication, leading to Cushing's Disease.

see more here: Cushing’s Disease in Dogs - Causes and Treatment Options
 
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